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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
|
|---|---|
| Published in |
Scientific Reports, May 2017
|
| DOI | 10.1038/s41598-017-02587-2 |
| Pubmed ID | |
| Authors |
Laura Bonfili, Valentina Cecarini, Sara Berardi, Silvia Scarpona, Jan S. Suchodolski, Cinzia Nasuti, Dennis Fiorini, Maria Chiara Boarelli, Giacomo Rossi, Anna Maria Eleuteri |
| Abstract |
Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer's disease (AD). Current AD treatments aim to prevent onset, delay progression and ameliorate symptoms. In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic formulation, thereby affecting the composition of gut microbiota and its metabolites. This influenced plasma concentration of inflammatory cytokines and key metabolic hormones considered therapeutic targets in neurodegeneration. Treated mice showed partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy). Their cognitive decline was decreased compared with controls, due to a reduction in brain damage and reduced accumulation of amyloid beta aggregates. Collectively, our results clearly prove that modulation of the microbiota induces positive effects on neuronal pathways that are able to slow down the progression of Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 24% |
| Canada | 2 | 8% |
| Denmark | 1 | 4% |
| France | 1 | 4% |
| Japan | 1 | 4% |
| Unknown | 14 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 68% |
| Scientists | 5 | 20% |
| Practitioners (doctors, other healthcare professionals) | 3 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 496 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 495 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 62 | 13% |
| Student > Master | 61 | 12% |
| Researcher | 45 | 9% |
| Student > Ph. D. Student | 43 | 9% |
| Student > Doctoral Student | 30 | 6% |
| Other | 75 | 15% |
| Unknown | 180 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 12% |
| Neuroscience | 51 | 10% |
| Medicine and Dentistry | 41 | 8% |
| Agricultural and Biological Sciences | 36 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 29 | 6% |
| Other | 86 | 17% |
| Unknown | 193 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2018.
All research outputs
#1,184,992
of 25,097,836 outputs
Outputs from Scientific Reports
#11,815
of 137,794 outputs
Outputs of similar age
#23,315
of 319,217 outputs
Outputs of similar age from Scientific Reports
#349
of 3,785 outputs
Altmetric has tracked 25,097,836 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 137,794 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 3,785 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.