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Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells

Overview of attention for article published in Molecular Cancer Therapeutics, March 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

twitter
61 tweeters
patent
1 patent
facebook
2 Facebook pages
googleplus
1 Google+ user

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
31 Mendeley
connotea
1 Connotea
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Title
Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells
Published in
Molecular Cancer Therapeutics, March 2005
DOI 10.1158/1535-7163.mct-03-0266
Pubmed ID
Authors

Lijuan Xia, Duo Chen, Rui Han, Qicheng Fang, Samuel Waxman, Yongkui Jing

Abstract

The mechanism of the cytotoxic effect of boswellic acid acetate, a 1:1 mixture of alpha-boswellic acid acetate and beta-boswellic acid acetate, isolated from Boswellia carterri Birdw on myeloid leukemia cells was investigated in six human myeloid leukemia cell lines (NB4, SKNO-1, K562, U937, ML-1, and HL-60 cells). Morphologic and DNA fragmentation assays indicated that the cytotoxic effect of boswellic acid acetate was mediated by induction of apoptosis. More than 50% of the cells underwent apoptosis after treatment with 20 mug/mL boswellic acid for 24 hours. This apoptotic process was p53 independent. The levels of apoptosis-related proteins Bcl-2, Bax, and Bcl-XL were not modulated by boswellic acid acetate. Boswellic acid acetate induced Bid cleavage and decreased mitochondrial membrane potential without production of hydrogen peroxide. A general caspase inhibitor (Z-VAD-FMK) and a specific caspase-8 inhibitor II (Z-IETD-FMK) blocked boswellic acid acetate-induced apoptosis. The mRNAs of death receptors 4 and 5 (DR4 and DR5) were induced in leukemia cells undergoing apoptosis after boswellic acid acetate treatment. These data taken together suggest that boswellic acid acetate induces myeloid leukemia cell apoptosis through activation of caspase-8 by induced expression of DR4 and DR5, and that the activated caspase-8 either directly activates caspase-3 by cleavage or indirectly by cleaving Bid, which in turn decreases mitochondria membrane potential.

Twitter Demographics

The data shown below were collected from the profiles of 61 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 16%
Researcher 5 16%
Student > Bachelor 2 6%
Other 2 6%
Professor > Associate Professor 2 6%
Other 5 16%
Unknown 10 32%
Readers by discipline Count As %
Nursing and Health Professions 4 13%
Biochemistry, Genetics and Molecular Biology 4 13%
Medicine and Dentistry 4 13%
Agricultural and Biological Sciences 2 6%
Philosophy 1 3%
Other 3 10%
Unknown 13 42%

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2022.
All research outputs
#707,956
of 21,752,314 outputs
Outputs from Molecular Cancer Therapeutics
#78
of 3,782 outputs
Outputs of similar age
#8,462
of 288,450 outputs
Outputs of similar age from Molecular Cancer Therapeutics
#3
of 55 outputs
Altmetric has tracked 21,752,314 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,782 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.