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Endoplasmic reticulum stress and inflammation in the central nervous system

Overview of attention for article published in Molecular Neurodegeneration, May 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)

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202 Dimensions

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219 Mendeley
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Title
Endoplasmic reticulum stress and inflammation in the central nervous system
Published in
Molecular Neurodegeneration, May 2017
DOI 10.1186/s13024-017-0183-y
Pubmed ID
Authors

Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez, Gordon P. Meares

Abstract

Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolded proteins and concomitant induction of ER stress in neurons contributes to neuronal dysfunction. In addition, ER stress responses induced in the surrounding neuroglia may promote disease progression by coordinating damaging inflammatory responses, which help fuel a neurotoxic milieu. Nevertheless, there still remains a gap in knowledge regarding the cell-specific mechanisms by which ER stress mediates neuroinflammation. In this review, we will discuss recently uncovered inflammatory pathways linked to the ER stress response. Moreover, we will summarize the present literature delineating how ER stress is generated in Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis, and highlight how ER stress and neuroinflammation intersect mechanistically within the central nervous system. The mechanisms by which stress-induced inflammation contributes to the pathogenesis and progression of neurodegenerative diseases remain poorly understood. Further examination of this interplay could present unappreciated insights into the development of neurodegenerative diseases, and reveal new therapeutic targets.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 218 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 43 20%
Researcher 32 15%
Student > Master 31 14%
Student > Bachelor 20 9%
Student > Doctoral Student 13 6%
Other 29 13%
Unknown 51 23%
Readers by discipline Count As %
Neuroscience 44 20%
Biochemistry, Genetics and Molecular Biology 32 15%
Medicine and Dentistry 20 9%
Agricultural and Biological Sciences 18 8%
Pharmacology, Toxicology and Pharmaceutical Science 15 7%
Other 28 13%
Unknown 62 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2022.
All research outputs
#7,295,054
of 23,009,818 outputs
Outputs from Molecular Neurodegeneration
#588
of 854 outputs
Outputs of similar age
#115,591
of 313,692 outputs
Outputs of similar age from Molecular Neurodegeneration
#22
of 26 outputs
Altmetric has tracked 23,009,818 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 854 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.