Title |
Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose
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Published in |
Retrovirology, January 2014
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DOI | 10.1186/1742-4690-11-8 |
Pubmed ID | |
Authors |
Anton M Sholukh, Siddappa N Byrareddy, Vivekanandan Shanmuganathan, Girish Hemashettar, Samir K Lakhashe, Robert A Rasmussen, Jennifer D Watkins, Hemant K Vyas, Swati Thorat, Tania Brandstoetter, Muhammad M Mukhtar, John K Yoon, Francis J Novembre, Francois Villinger, Gary Landucci, Donald N Forthal, Sarah Ratcliffe, Iskra Tuero, Marjorie Robert-Guroff, Victoria R Polonis, Miroslawa Bilska, David C Montefiori, Welkin E Johnson, Hildegund C Ertl, Ruth M Ruprecht |
Abstract |
A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due to multiple HIV-1 quasispecies circulating in the human population worldwide, heterologous SHIV challenges are essential for realistic vaccine efficacy testing in primates. We assessed whether polyclonal IgG, isolated from rhesus monkeys (RMs) with high-titer nAbs (termed SHIVIG), could protect RMs against the R5-tropic tier-2 SHIV-2873Nip, which was heterologous to the viruses or HIV-1 envelopes that had elicited SHIVIG. |
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