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Emotional and Behavioral Symptoms in Neurodegenerative Disease: A Model for Studying the Neural Bases of Psychopathology

Overview of attention for article published in Annual Review of Clinical Psychology, January 2014
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Title
Emotional and Behavioral Symptoms in Neurodegenerative Disease: A Model for Studying the Neural Bases of Psychopathology
Published in
Annual Review of Clinical Psychology, January 2014
DOI 10.1146/annurev-clinpsy-032813-153653
Pubmed ID
Authors

Robert W. Levenson, Virginia E. Sturm, Claudia M. Haase

Abstract

Disruptions in emotional, cognitive, and social behavior are common in neurodegenerative disease and in many forms of psychopathology. Because neurodegenerative diseases have patterns of brain atrophy that are much clearer than those of psychiatric disorders, they may provide a window into the neural bases of common emotional and behavioral symptoms. We discuss five common symptoms that occur in both neurodegenerative disease and psychopathology (i.e., anxiety, dysphoric mood, apathy, disinhibition, and euphoric mood) and their associated neural circuitry. We focus on two neurodegenerative diseases (i.e., Alzheimer's disease and frontotemporal dementia) that are common and well characterized in terms of emotion, cognition, and social behavior and in patterns of associated atrophy. Neurodegenerative diseases provide a powerful model system for studying the neural correlates of psychopathological symptoms; this is supported by evidence indicating convergence with psychiatric syndromes (e.g., symptoms of disinhibition associated with dysfunction in orbitofrontal cortex in both frontotemporal dementia and bipolar disorder). We conclude that neurodegenerative diseases can play an important role in future approaches to the assessment, prevention, and treatment of mental illness.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 292 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
Philippines 1 <1%
Uruguay 1 <1%
Australia 1 <1%
Unknown 286 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 49 17%
Student > Master 40 14%
Student > Bachelor 34 12%
Researcher 33 11%
Student > Doctoral Student 22 8%
Other 42 14%
Unknown 72 25%
Readers by discipline Count As %
Psychology 61 21%
Medicine and Dentistry 39 13%
Neuroscience 39 13%
Biochemistry, Genetics and Molecular Biology 21 7%
Agricultural and Biological Sciences 21 7%
Other 32 11%
Unknown 79 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2019.
All research outputs
#15,169,543
of 25,374,647 outputs
Outputs from Annual Review of Clinical Psychology
#313
of 355 outputs
Outputs of similar age
#184,823
of 336,899 outputs
Outputs of similar age from Annual Review of Clinical Psychology
#21
of 23 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 355 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.8. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,899 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.