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Innate immunity and monocyte-macrophage activation in atherosclerosis

Overview of attention for article published in Journal of Inflammation, April 2011
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Title
Innate immunity and monocyte-macrophage activation in atherosclerosis
Published in
Journal of Inflammation, April 2011
DOI 10.1186/1476-9255-8-9
Pubmed ID
Authors

Joseph Shalhoub, Mika A Falck-Hansen, Alun H Davies, Claudia Monaco

Abstract

Innate inflammation is a hallmark of both experimental and human atherosclerosis. The predominant innate immune cell in the atherosclerotic plaque is the monocyte-macrophage. The behaviour of this cell type within the plaque is heterogeneous and depends on the recruitment of diverse monocyte subsets. Furthermore, the plaque microenvironment offers polarisation and activation signals which impact on phenotype. Microenvironmental signals are sensed through pattern recognition receptors, including toll-like and NOD-like receptors - the latter of which are components of the inflammasome - thus dictating macrophage behaviour and outcome in atherosclerosis. Recently cholesterol crystals and modified lipoproteins have been recognised as able to directly engage these pattern recognition receptors. The convergent role of such pathways in terms of macrophage activation is discussed in this review.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 2%
Germany 2 <1%
United States 2 <1%
Canada 2 <1%
Brazil 1 <1%
Ireland 1 <1%
Indonesia 1 <1%
Russia 1 <1%
Belgium 1 <1%
Other 2 <1%
Unknown 227 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 53 22%
Researcher 44 18%
Student > Master 31 13%
Professor > Associate Professor 17 7%
Student > Doctoral Student 15 6%
Other 61 25%
Unknown 24 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 95 39%
Medicine and Dentistry 58 24%
Biochemistry, Genetics and Molecular Biology 24 10%
Immunology and Microbiology 17 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 13 5%
Unknown 33 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2014.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Journal of Inflammation
#278
of 425 outputs
Outputs of similar age
#106,130
of 121,433 outputs
Outputs of similar age from Journal of Inflammation
#3
of 3 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 425 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,433 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.