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Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes

Overview of attention for article published in Cell & Bioscience, May 2017
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

4 tweeters


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Readers on

12 Mendeley
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Chloroquine inhibits Ca2+ permeable ion channels-mediated Ca2+ signaling in primary B lymphocytes
Published in
Cell & Bioscience, May 2017
DOI 10.1186/s13578-017-0155-5
Pubmed ID

Yi-Fan Wu, Ping Zhao, Xi Luo, Jin-Chao Xu, Lu Xue, Qi Zhou, Mingrui Xiong, Jinhua Shen, Yong-Bo Peng, Meng-Fei Yu, Weiwei Chen, Liqun Ma, Qing-Hua Liu


Chloroquine, a bitter tastant, inhibits Ca(2+) signaling, resulting in suppression of B cell activation; however, the inhibitory mechanism remains unclear. In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca(2+) increases in mouse splenic primary B lymphocytes, which were markedly inhibited by chloroquine. Under Ca(2+)-free conditions, TG elicited transient Ca(2+) increases, which additionally elevated upon the restoration of 2 mM Ca(2+). The former were from release of intracellular Ca(2+) store and the latter from Ca(2+) influx. TG-induced release was inhibited by 2-APB (an inhibitor of inositol-3-phosphate receptors, IP3Rs) and chloroquine, and TG-caused influx was inhibited by pyrazole (Pyr3, an inhibitor of transient receptor potential C3 (TRPC3) and stromal interaction molecule (STIM)/Orai channels) and chloroquine. Moreover, chloroquine also blocked Ca(2+) increases induced by the engagement of B cell receptor (BCR) with anti-IgM. These results indicate that chloroquine inhibits Ca(2+) elevations in splenic B cells through inhibiting Ca(2+) permeable IP3R and TRPC3 and/or STIM/Orai channels. These findings suggest that chloroquine would be a potent immunosuppressant.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Professor 2 17%
Student > Bachelor 2 17%
Student > Ph. D. Student 1 8%
Librarian 1 8%
Student > Doctoral Student 1 8%
Other 4 33%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 3 25%
Immunology and Microbiology 3 25%
Biochemistry, Genetics and Molecular Biology 2 17%
Physics and Astronomy 1 8%
Agricultural and Biological Sciences 1 8%
Other 0 0%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2020.
All research outputs
of 15,383,358 outputs
Outputs from Cell & Bioscience
of 420 outputs
Outputs of similar age
of 270,161 outputs
Outputs of similar age from Cell & Bioscience
of 2 outputs
Altmetric has tracked 15,383,358 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 420 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them