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Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats

Overview of attention for article published in Acta Cirurgica Brasileira, October 2016
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Title
Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats
Published in
Acta Cirurgica Brasileira, October 2016
DOI 10.1590/s0102-865020160100000004
Pubmed ID
27828599
Authors

Zhigang Qin, Guijie Li, Naijie Liu, Conghai Zhao, Hang Zhao

Abstract

To develop a model for studying cerebrovascular disease prevention in elderly women. Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were allocated to a control group. The EA group received estradiol benzoate starting on the 5th day of a 34-day breeding period, and the serum levels of estradiol (E2), estrogen receptor (ER), and malondialdehyde (MDA) were measured. The MCA of each group was then sampled for viscoelastic experiments. The serum levels of E2 and MDA in the EA group showed significant differences compared to those in the control group (p<0.05), while the difference in ER between the EA and control groups was not significant (p>0.05). The decrease in MCA stress at 7,200 s and the increase in strain at 7,200 s in the EA group showed no significant differences compared to the control group (p>0.05). Estradiol administration inhibited the formation of lipid peroxidation products and restored middle cerebral arterial viscoelasticity in aged female rats.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 2 67%
Student > Doctoral Student 1 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 33%
Neuroscience 1 33%
Engineering 1 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2017.
All research outputs
#20,425,762
of 22,977,819 outputs
Outputs from Acta Cirurgica Brasileira
#162
of 212 outputs
Outputs of similar age
#281,881
of 324,831 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#2
of 3 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 212 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,831 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.

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