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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

Overview of attention for article published in Nature Genetics, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

blogs
2 blogs
twitter
3 tweeters
patent
1 patent
wikipedia
4 Wikipedia pages

Citations

dimensions_citation
285 Dimensions

Readers on

mendeley
204 Mendeley
citeulike
3 CiteULike
Title
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
Published in
Nature Genetics, August 2011
DOI 10.1038/ng.903
Pubmed ID
Authors

Meng Li, Hong Zhao, Xiaosong Zhang, Laura D Wood, Robert A Anders, Michael A Choti, Timothy M Pawlik, Hubert D Daniel, Rajesh Kannangai, G Johan A Offerhaus, Victor E Velculescu, Linfang Wang, Shibin Zhou, Bert Vogelstein, Ralph H Hruban, Nick Papadopoulos, Jianqiang Cai, Michael S Torbenson, Kenneth W Kinzler

Abstract

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 2%
Italy 2 <1%
France 2 <1%
Japan 2 <1%
China 2 <1%
Denmark 1 <1%
Hong Kong 1 <1%
Unknown 189 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 55 27%
Researcher 55 27%
Student > Master 15 7%
Student > Doctoral Student 14 7%
Unspecified 13 6%
Other 52 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 99 49%
Medicine and Dentistry 45 22%
Biochemistry, Genetics and Molecular Biology 34 17%
Unspecified 18 9%
Mathematics 2 <1%
Other 6 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2017.
All research outputs
#636,182
of 12,196,902 outputs
Outputs from Nature Genetics
#1,406
of 5,987 outputs
Outputs of similar age
#4,716
of 90,397 outputs
Outputs of similar age from Nature Genetics
#19
of 67 outputs
Altmetric has tracked 12,196,902 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,987 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.1. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.