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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Direct reprogramming of fibroblasts into cardiomyocytes
|
|---|---|
| Published in |
Stem Cell Research & Therapy, May 2017
|
| DOI | 10.1186/s13287-017-0569-3 |
| Pubmed ID | |
| Authors |
Yueqiu Chen, Ziying Yang, Zhen-Ao Zhao, Zhenya Shen |
| Abstract |
Cardiovascular diseases are the leading causes of death in the world. The limited regenerative capacity of adult cardiomyocytes is the major barrier for heart regeneration. After myocardial infarction, myofibroblasts are the dominant cell type in the infarct zone. Therefore, it is a good idea to reprogram terminally differentiated myofibroblasts into cardiomyocyte-like cells directly, providing a good strategy to simultaneously reduce scar tissue and increase functional cardiomyocytes. Transcription factors were first identified to reprogram myofibroblasts into cardiomyocytes. Thereafter, microRNAs and/or small molecules showed great potential to optimize the reprogramming process. Here, we systemically summarize and compare the major progress in directed cardiac reprogramming including transcription factors and miRNAs, especially the small molecules. Furthermore, we discuss the challenges needed to be overcome to apply this strategy clinically. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 169 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 14% |
| Student > Bachelor | 24 | 14% |
| Student > Ph. D. Student | 21 | 12% |
| Student > Master | 20 | 12% |
| Student > Doctoral Student | 13 | 8% |
| Other | 30 | 18% |
| Unknown | 37 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 33% |
| Medicine and Dentistry | 23 | 14% |
| Agricultural and Biological Sciences | 17 | 10% |
| Engineering | 12 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 13 | 8% |
| Unknown | 42 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#6,773,052
of 24,585,562 outputs
Outputs from Stem Cell Research & Therapy
#656
of 2,648 outputs
Outputs of similar age
#100,772
of 318,023 outputs
Outputs of similar age from Stem Cell Research & Therapy
#16
of 67 outputs
Altmetric has tracked 24,585,562 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 2,648 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,023 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.