| Chapter title |
MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
|
|---|---|
| Chapter number | 4 |
| Book title |
Bioinformatics in MicroRNA Research
|
| Published in |
Methods in molecular biology, May 2017
|
| DOI | 10.1007/978-1-4939-7046-9_4 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7044-5, 978-1-4939-7046-9
|
| Authors |
Weili Huang Ph.D., Weili Huang, Huang, Weili |
| Editors |
Jingshan Huang, Glen M. Borchert, Dejing Dou, Jun (Luke) Huan, Wenjun Lan, Ming Tan, Bin Wu |
| Abstract |
MicroRNAs (miRNAs) are small noncoding RNAs (21-23 nucleotides in length) that regulate gene expression at translational or posttranslational levels. The major regulatory mechanisms include translational repression or mRNA degradation (Filipowicz et al., Curr Opin Struct Biol 15:331-341, 2005).Aberrant expression of miRNAs has been found to be associated with a variety of human diseases such as cancers/tumors, diabetes, viral infections, cardiovascular diseases, neurodegenerative diseases, and other diseases (Wang et al., J Cell Physiol 23:25-30, 2016; Lawrie, MicroRNAs in medicine, 2013). The expression of miRNAs is tissue specific and can be used to identify tumor type and its origin (Mishra and Merlino, J Clin Invest 119:2119-2123, 2009). Many investigations suggest that the miRNA-expression profiles are novel diagnostic and prognostic biomarkers for multiple human diseases. Manipulating relevant miRNA expression or function may serve as potential therapeutic strategies for different diseases. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 184 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 13% |
| Student > Master | 22 | 12% |
| Student > Bachelor | 21 | 11% |
| Researcher | 20 | 11% |
| Student > Doctoral Student | 9 | 5% |
| Other | 21 | 11% |
| Unknown | 68 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 53 | 29% |
| Medicine and Dentistry | 15 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Agricultural and Biological Sciences | 7 | 4% |
| Veterinary Science and Veterinary Medicine | 5 | 3% |
| Other | 16 | 9% |
| Unknown | 79 | 43% |