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Bioinformatics in MicroRNA Research

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Cover of 'Bioinformatics in MicroRNA Research'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease
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    Chapter 2 MicroRNA Expression: Protein Participants in MicroRNA Regulation
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    Chapter 3 Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs
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    Chapter 4 MicroRNAs: Biomarkers, Diagnostics, and Therapeutics
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    Chapter 5 Relational Databases and Biomedical Big Data
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    Chapter 6 Semantic Technologies and Bio-Ontologies
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    Chapter 7 Genome-Wide Analysis of MicroRNA-Regulated Transcripts
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    Chapter 8 Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources
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    Chapter 9 Exploring MicroRNA::Target Regulatory Interactions by Computing Technologies
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    Chapter 10 The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy.
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    Chapter 11 Genomic Regulation of MicroRNA Expression in Disease Development
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    Chapter 12 Next-Generation Sequencing for MicroRNA Expression Profile
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    Chapter 13 Handling High-Dimension (High-Feature) MicroRNA Data.
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    Chapter 14 Effective Removal of Noisy Data Via Batch Effect Processing
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    Chapter 15 Logical Reasoning (Inferencing) on MicroRNA Data
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    Chapter 16 Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions
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    Chapter 17 Involvement of MicroRNAs in Diabetes and Its Complications
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    Chapter 18 MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role.
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    Chapter 19 Expression of MicroRNAs in Thyroid Carcinoma.
Attention for Chapter 2: MicroRNA Expression: Protein Participants in MicroRNA Regulation
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Chapter title
MicroRNA Expression: Protein Participants in MicroRNA Regulation
Chapter number 2
Book title
Bioinformatics in MicroRNA Research
Published in
Methods in molecular biology, May 2017
DOI 10.1007/978-1-4939-7046-9_2
Pubmed ID
Book ISBNs
978-1-4939-7044-5, 978-1-4939-7046-9
Authors

Valeria M. King, Glen M. Borchert Ph.D., Glen M. Borchert

Editors

Jingshan Huang, Glen M. Borchert, Dejing Dou, Jun (Luke) Huan, Wenjun Lan, Ming Tan, Bin Wu

Abstract

MiRNAs are ~20 nt small RNAs that regulate networks of proteins using a seed region of nucleotides 2-8 to complement the 3' UTR of target mRNAs. The biogenesis and function of miRNAs as translational repressors is facilitated by protein counterparts that process primary and precursor miRNAs to maturity (Drosha/DCGR8 and Dicer/TRBP respectively) and incorporate miRNAs into the protein complex RISC to recognize and repress target mRNAs (RISC proteins: Ago/TRBP1/TRBP2/DICER). Similarly, siRNAs through comparable mechanisms are loaded into the protein complex RITS to heterochromatin formation of DNA and suppress transcription of particular genes. MiRNAs are also regulated themselves through many different pathways including transcriptional regulation, post-transcriptional RNA editing, and RNA tailing. Dysregulation of miRNAs and the protein participants that mature them are implicated in the development of a number of diseases, tumorigenesis, and arrested development of embryonic cells. In this chapter, we will explore the biosynthesis, function, and regulation of miRNAs.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 42%
Student > Doctoral Student 2 17%
Professor > Associate Professor 1 8%
Student > Master 1 8%
Unknown 3 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 42%
Agricultural and Biological Sciences 2 17%
Chemical Engineering 1 8%
Chemistry 1 8%
Unknown 3 25%