Expression of MicroRNAs in Thyroid Carcinoma.
Bioinformatics in MicroRNA Research
Methods in molecular biology, January 2017
Gaohong Zhu M.D., Lijun Xie, Daniel Miller, Gaohong Zhu
Jingshan Huang, Glen M. Borchert, Dejing Dou, Jun (Luke) Huan, Wenjun Lan, Ming Tan, Bin Wu
MicroRNA (miRNA) are negative regulators of gene expression and subsequent protein production. This method of action translates into regulatory control over cellular processes, including development, signaling, metabolism, and apoptosis. A broad range of miRNA are shown to have abnormal expressions in thyroid cancers which could explain the pathology of tumor oncogenesis and disease progression. A review is conducted of the current research on miRNA dysregulation in thyroid cancers, including papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), anaplastic thyroid cancer (ATC), and medullary thyroid carcinoma (MTC). Dysregulated miRNA and their associated regulatory pathways are identified and their oncogenic and pathological significance are discussed.
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