MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role.
Bioinformatics in MicroRNA Research
Methods in molecular biology, January 2017
Lihua Zhang, Daniel Miller, Qiuping Yang, Bin Wu M.D., Ph.D., Bin Wu
Jingshan Huang, Glen M. Borchert, Dejing Dou, Jun (Luke) Huan, Wenjun Lan, Ming Tan, Bin Wu
Even though it is a pandemic health problem worldwide, the pathogenesis of obesity is poorly understood. Recently, emerging studies verified that microRNAs (miRNAs) are involved in complicated metabolic processes including adipocyte differentiation, fat cell formation (adipogenesis), obesity-related insulin resistance and inflammation. Many regulatory networks have been identified in murine adipose tissue, but those in human adipose tissue are not as well known. In addition, miRNAs have been detected in circulation, and thus may be usable as diagnostic indicators. MiRNAs may play an important part in regulating metabolic functions in adipose tissues and, by extension, obesity and its associated disorders. Consequently, they may be potential candidates for therapeutic targets and biomarkers.
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