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Caveolin-1 is required for lateral line neuromast and notochord development

Overview of attention for article published in Journal of Cell Science, June 2007
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
31 Dimensions

Readers on

mendeley
36 Mendeley
Title
Caveolin-1 is required for lateral line neuromast and notochord development
Published in
Journal of Cell Science, June 2007
DOI 10.1242/jcs.003830
Pubmed ID
Authors

S. J. Nixon, A. Carter, J. Wegner, C. Ferguson, M. Floetenmeyer, J. Riches, B. Key, M. Westerfield, R. G. Parton

Abstract

Caveolae have been linked to diverse cellular functions and to many disease states. In this study we have used zebrafish to examine the role of caveolin-1 and caveolae during early embryonic development. During development, expression is apparent in a number of tissues including Kupffer's vesicle, tailbud, intersomite boundaries, heart, branchial arches, pronephric ducts and periderm. Particularly strong expression is observed in the sensory organs of the lateral line, the neuromasts and in the notochord where it overlaps with expression of caveolin-3. Morpholino-mediated downregulation of Cav1alpha caused a dramatic inhibition of neuromast formation. Detailed ultrastructural analysis, including electron tomography of the notochord, revealed that the central regions of the notochord has the highest density of caveolae of any embryonic tissue comparable to the highest density observed in any vertebrate tissue. In addition, Cav1alpha downregulation caused disruption of the notochord, an effect that was enhanced further by Cav3 knockdown. These results indicate an essential role for caveolin and caveolae in this vital structural and signalling component of the embryo.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
Chile 1 3%
United States 1 3%
Greece 1 3%
Unknown 32 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 36%
Student > Ph. D. Student 9 25%
Professor > Associate Professor 4 11%
Student > Bachelor 4 11%
Student > Master 3 8%
Other 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 64%
Biochemistry, Genetics and Molecular Biology 3 8%
Medicine and Dentistry 3 8%
Neuroscience 3 8%
Physics and Astronomy 2 6%
Other 3 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2017.
All research outputs
#2,987,159
of 11,130,136 outputs
Outputs from Journal of Cell Science
#1,089
of 4,275 outputs
Outputs of similar age
#91,493
of 265,692 outputs
Outputs of similar age from Journal of Cell Science
#29
of 86 outputs
Altmetric has tracked 11,130,136 research outputs across all sources so far. This one has received more attention than most of these and is in the 50th percentile.
So far Altmetric has tracked 4,275 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.