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The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits

Overview of attention for article published in Biology Direct, April 2007
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Title
The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits
Published in
Biology Direct, April 2007
DOI 10.1186/1745-6150-2-10
Pubmed ID
Authors

William FN Chan, Ainhoa Perez-Diez, Haide Razavy, Colin C Anderson

Abstract

Transplant rejection has been considered to occur primarily because donor antigens are not present during the development of the recipient's immune system to induce tolerance. Thus, transplantation prior to recipient immune system development (pre-immunocompetence transplants) should induce natural tolerance to the donor. Surprisingly, tolerance was often not the outcome in such 'natural tolerance models'. We explored the ability of natural tolerance to prevent immune responses to alloantigens, and the reasons for the disparate outcomes of pre-immunocompetence transplants.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 11%
Unknown 8 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 44%
Professor > Associate Professor 2 22%
Student > Ph. D. Student 1 11%
Student > Doctoral Student 1 11%
Unknown 1 11%
Readers by discipline Count As %
Medicine and Dentistry 2 22%
Agricultural and Biological Sciences 2 22%
Biochemistry, Genetics and Molecular Biology 1 11%
Immunology and Microbiology 1 11%
Neuroscience 1 11%
Other 0 0%
Unknown 2 22%