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Mendeley readers
| Title |
Cancer models, genomic instability and somatic cellular Darwinian evolution
|
|---|---|
| Published in |
Biology Direct, April 2010
|
| DOI | 10.1186/1745-6150-5-19 |
| Pubmed ID | |
| Authors |
Mark P Little |
| Abstract |
The biology of cancer is critically reviewed and evidence adduced that its development can be modelled as a somatic cellular Darwinian evolutionary process. The evidence for involvement of genomic instability (GI) is also reviewed. A variety of quasi-mechanistic models of carcinogenesis are reviewed, all based on this somatic Darwinian evolutionary hypothesis; in particular, the multi-stage model of Armitage and Doll (Br. J. Cancer 1954:8;1-12), the two-mutation model of Moolgavkar, Venzon, and Knudson (MVK) (Math. Biosci. 1979:47;55-77), the generalized MVK model of Little (Biometrics 1995:51;1278-1291) and various generalizations of these incorporating effects of GI (Little and Wright Math. Biosci. 2003:183;111-134; Little et al. J. Theoret. Biol. 2008:254;229-238). |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 6% |
| United Kingdom | 2 | 2% |
| Germany | 1 | 1% |
| France | 1 | 1% |
| Brazil | 1 | 1% |
| Portugal | 1 | 1% |
| Mexico | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 79 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 27% |
| Student > Ph. D. Student | 18 | 19% |
| Student > Bachelor | 9 | 10% |
| Student > Master | 9 | 10% |
| Student > Postgraduate | 7 | 8% |
| Other | 16 | 17% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 45% |
| Medicine and Dentistry | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Physics and Astronomy | 5 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 11 | 12% |