Title |
Method of predicting Splice Sites based on signal interactions
|
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Published in |
Biology Direct, April 2006
|
DOI | 10.1186/1745-6150-1-10 |
Pubmed ID | |
Authors |
Alexander Churbanov, Igor B Rogozin, Jitender S Deogun, Hesham Ali |
Abstract |
Predicting and proper ranking of canonical splice sites (SSs) is a challenging problem in bioinformatics and machine learning communities. Any progress in SSs recognition will lead to better understanding of splicing mechanism. We introduce several new approaches of combining a priori knowledge for improved SS detection. First, we design our new Bayesian SS sensor based on oligonucleotide counting. To further enhance prediction quality, we applied our new de novo motif detection tool MHMMotif to intronic ends and exons. We combine elements found with sensor information using Naive Bayesian Network, as implemented in our new tool SpliceScan. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 7% |
United Kingdom | 1 | 2% |
India | 1 | 2% |
Saudi Arabia | 1 | 2% |
Unknown | 36 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 26% |
Researcher | 9 | 21% |
Student > Master | 6 | 14% |
Other | 4 | 10% |
Student > Bachelor | 3 | 7% |
Other | 4 | 10% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 50% |
Computer Science | 5 | 12% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Medicine and Dentistry | 3 | 7% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 2 | 5% |
Unknown | 6 | 14% |