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ConReg-R: Extrapolative recalibration of the empirical distribution of p-values to improve false discovery rate estimates

Overview of attention for article published in Biology Direct, May 2011
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Title
ConReg-R: Extrapolative recalibration of the empirical distribution of p-values to improve false discovery rate estimates
Published in
Biology Direct, May 2011
DOI 10.1186/1745-6150-6-27
Pubmed ID
Authors

Juntao Li, Puteri Paramita, Kwok Pui Choi, R Krishna Murthy Karuturi

Abstract

False discovery rate (FDR) control is commonly accepted as the most appropriate error control in multiple hypothesis testing problems. The accuracy of FDR estimation depends on the accuracy of the estimation of p-values from each test and validity of the underlying assumptions of the distribution. However, in many practical testing problems such as in genomics, the p-values could be under-estimated or over-estimated for many known or unknown reasons. Consequently, FDR estimation would then be influenced and lose its veracity.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 7%
Netherlands 1 4%
Spain 1 4%
Unknown 24 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 39%
Student > Ph. D. Student 5 18%
Professor 3 11%
Student > Master 3 11%
Professor > Associate Professor 2 7%
Other 2 7%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 64%
Biochemistry, Genetics and Molecular Biology 2 7%
Computer Science 2 7%
Mathematics 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 3 11%
Unknown 1 4%