Title |
Same-strand overlapping genes in bacteria: compositional determinants of phase bias
|
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Published in |
Biology Direct, August 2008
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DOI | 10.1186/1745-6150-3-36 |
Pubmed ID | |
Authors |
Niv Sabath, Dan Graur, Giddy Landan |
Abstract |
Same-strand overlapping genes may occur in frameshifts of one (phase 1) or two nucleotides (phase 2). In previous studies of bacterial genomes, long phase-1 overlaps were found to be more numerous than long phase-2 overlaps. This bias was explained by either genomic location or an unspecified selection advantage. Models that focused on the ability of the two genes to evolve independently did not predict this phase bias. Here, we propose that a purely compositional model explains the phase bias in a more parsimonious manner. Same-strand overlapping genes may arise through either a mutation at the termination codon of the upstream gene or a mutation at the initiation codon of the downstream gene. We hypothesized that given these two scenarios, the frequencies of initiation and termination codons in the two phases may determine the number for overlapping genes. |
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