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Transcription factor binding sites are highly enriched within microRNA precursor sequences

Overview of attention for article published in Biology Direct, December 2011
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Title
Transcription factor binding sites are highly enriched within microRNA precursor sequences
Published in
Biology Direct, December 2011
DOI 10.1186/1745-6150-6-61
Pubmed ID
Authors

Jittima Piriyapongsa, I King Jordan, Andrew B Conley, Tom Ronan, Neil R Smalheiser

Abstract

Transcription factors are thought to regulate the transcription of microRNA genes in a manner similar to that of protein-coding genes; that is, by binding to conventional transcription factor binding site DNA sequences located in or near promoter regions that lie upstream of the microRNA genes. However, in the course of analyzing the genomics of human microRNA genes, we noticed that annotated transcription factor binding sites commonly lie within 70- to 110-nt long microRNA small hairpin precursor sequences.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 5%
United States 2 4%
Italy 1 2%
Czechia 1 2%
Germany 1 2%
Unknown 49 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 26%
Student > Ph. D. Student 14 25%
Student > Master 8 14%
Other 4 7%
Student > Postgraduate 3 5%
Other 9 16%
Unknown 4 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 53%
Biochemistry, Genetics and Molecular Biology 13 23%
Medicine and Dentistry 5 9%
Neuroscience 2 4%
Immunology and Microbiology 1 2%
Other 1 2%
Unknown 5 9%