Title |
Increased IL-4 mRNA expression and poly-aromatic hydrocarbon concentrations from children with asthma
|
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Published in |
BMC Pediatrics, January 2014
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DOI | 10.1186/1471-2431-14-17 |
Pubmed ID | |
Authors |
Nasser M Al-Daghri, Sherif Abd-Alrahman, Hossam Draz, Khalid Alkharfy, Abdul Khader Mohammed, Mario S Clerici, Majed S Alokail |
Abstract |
Asthma is the most common chronic childhood disease. Imbalance of cytokines released from T helper cells and environmental factors, such as exposure to poly-aromatic hydrocarbon (PAH), play pivotal roles in the pathogenesis of asthma. The aim of this study was to compare the mRNA expression patterns of Interleukin (IL)-4, interferon (IFN)-γ and Acyl Co A long chain 3 (ACSL3) in peripheral blood leukocytes of children with and without asthma. To correlate the obtained mRNA data with serum IL-4, IFN-γ and PAH levels. Further, to determine the effect of in vivo exposure to PAH on mRNA expression of IL-4, IFN-γ and ACSL3 genes in a rat model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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South Africa | 1 | 3% |
Unknown | 33 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 21% |
Researcher | 6 | 18% |
Professor | 5 | 15% |
Student > Master | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 5 | 15% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Immunology and Microbiology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 5 | 15% |
Unknown | 7 | 21% |