Title |
Transgenic Zebrafish Reveal Tissue-Specific Differences in Estrogen Signaling in Response to Environmental Water Samples
|
---|---|
Published in |
Environmental Health Perspectives, January 2014
|
DOI | 10.1289/ehp.1307329 |
Pubmed ID | |
Authors |
Daniel A. Gorelick, Luke R. Iwanowicz, Alice L. Hung, Vicki S. Blazer, Marnie E. Halpern |
Abstract |
Environmental endocrine disruptors (EEDs) are exogenous chemicals that mimic endogenous hormones such as estrogens. Previous studies using a zebrafish transgenic reporter demonstrated that the EEDs bisphenol A and genistein preferentially activate estrogen receptors (ERs) in the larval heart compared with the liver. However, it was not known whether the transgenic zebrafish reporter was sensitive enough to detect estrogens from environmental samples, whether environmental estrogens would exhibit tissue-specific effects similar to those of BPA and genistein, or why some compounds preferentially target receptors in the heart. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 2% |
United States | 2 | 2% |
Unknown | 85 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 22% |
Student > Ph. D. Student | 15 | 17% |
Student > Bachelor | 14 | 16% |
Researcher | 13 | 15% |
Student > Doctoral Student | 4 | 4% |
Other | 12 | 13% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 28% |
Biochemistry, Genetics and Molecular Biology | 19 | 21% |
Environmental Science | 10 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
Neuroscience | 5 | 6% |
Other | 11 | 12% |
Unknown | 13 | 15% |