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Transanal endoscopic operation for rectal cancer after neoadjuvant therapy

Overview of attention for article published in Acta Cirurgica Brasileira, January 2016
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Title
Transanal endoscopic operation for rectal cancer after neoadjuvant therapy
Published in
Acta Cirurgica Brasileira, January 2016
DOI 10.1590/s0102-86502016001300007
Pubmed ID
Authors

José Joaquim Ribeiro da Rocha, Mário Vinícius Angelete Alvarez Bernardes, Marley Ribeiro Feitosa, Camila Perazzoli, Vanessa Foresto Machado, Fernanda Maris Peria, Harley Francisco de Oliveira, Omar Feres

Abstract

In this paper we report the oncological outcomes from clinical series of patients with rectal cancer submitted to local excision after neoadjuvant therapy and discuss the indications for local excision in partial clinical responders. We analysed a prospective database of 39 patients submitted to a transanal endoscopic operation for rectal cancer after neoadjuvant chemoradiation between 2006 and 2015, comparing clinical and pathological variables, perioperative complications, recurrence rate and overall survival. We obtained 15.4% ypT0, 17.9% ypT1, 35.9% ypT2 and 28.2% ypT3. After a median follow-up of 24 months, tumoral recurrence was observed in 4 patients, one of them with isolated pulmonary metastasis. R0 resection was achieved in 79.5%, and postoperative complications were observed in 30.2% patients and no perioperative mortality occur. Compromise surgical margins do not affect recurrence rate, and 94.9% of patients are alive nowadays. Local excision could be associated with low recurrence rate and good overall survival. Short hospitalization time and low level of serious complications observed could be an interesting option for patients who would not tolerate a radical procedure or for those who declined a total mesorectal excision. A strict long-term follow-up must be warranted to detect early tumoral recurrence.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 17%
Student > Bachelor 2 11%
Professor 2 11%
Researcher 2 11%
Student > Postgraduate 2 11%
Other 0 0%
Unknown 7 39%
Readers by discipline Count As %
Medicine and Dentistry 8 44%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Unknown 9 50%