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Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis

Overview of attention for article published in Anais Brasileiros de Dermatologia, October 2016
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Title
Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis
Published in
Anais Brasileiros de Dermatologia, October 2016
DOI 10.1590/abd1806-4841.20164860
Pubmed ID
Authors

Giancarlo Rezende Bessa, Vanessa Petry Quinto, Daiane Corrêa Machado, Caroline Lipnharski, Magda Blessmann Weber, Renan Rangel Bonamigo, Pedro Alves D'Azevedo

Abstract

Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization. To evaluate the prevalence of Staphylococcus aureus topical antimicrobial drug resistance in atopic dermatitis patients. We conducted a cross-sectional study of children and adults diagnosed with atopic dermatitis and S. aureus colonization. We used miscellaneous literature reported breakpoints to define S. aureus resistance to mupirocin, fusidic acid, gentamicin, neomycin and bacitracin. A total of 91 patients were included and 100 S. aureus isolates were analyzed. All strains were methicillin-susceptible S. aureus. We found a low prevalence of mupirocin and fusidic acid resistance (1.1% and 5.9%, respectively), but high levels of neomycin and bacitracin resistance (42.6% and 100%, respectively). Fusidic acid resistance was associated with more severe atopic dermatitis, demonstrated by higher EASI scores (median 17.8 vs 5.7, p=.009). Our results also corroborate the literature on the absence of cross-resistance between the aminoglycosides neomycin and gentamicin. Our data, in a southern Brazilian sample of AD patients, revealed a low prevalence of mupirocin and fusidic acid resistance of S. aureus atopic eczema colonizer strains. However, for neomycin and bacitracin, which are commonly used topical antimicrobial drugs in Brazil, high levels of resistance were identified. Further restrictions on the use of these antimicrobials seem necessary to keep resistance as low as possible.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 21%
Researcher 8 11%
Student > Ph. D. Student 8 11%
Student > Master 6 8%
Other 6 8%
Other 14 19%
Unknown 17 23%
Readers by discipline Count As %
Medicine and Dentistry 17 23%
Pharmacology, Toxicology and Pharmaceutical Science 9 12%
Agricultural and Biological Sciences 7 9%
Biochemistry, Genetics and Molecular Biology 7 9%
Immunology and Microbiology 4 5%
Other 12 16%
Unknown 19 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2017.
All research outputs
#10,092,608
of 11,379,716 outputs
Outputs from Anais Brasileiros de Dermatologia
#288
of 363 outputs
Outputs of similar age
#223,120
of 267,343 outputs
Outputs of similar age from Anais Brasileiros de Dermatologia
#4
of 8 outputs
Altmetric has tracked 11,379,716 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 363 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,343 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.