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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update
|
|---|---|
| Published in |
Clinical Pharmacology & Therapeutics, January 2014
|
| DOI | 10.1038/clpt.2013.254 |
| Pubmed ID | |
| Authors |
K R Crews, A Gaedigk, H M Dunnenberger, J S Leeder, T E Klein, K E Caudle, C E Haidar, D D Shen, J T Callaghan, S Sadhasivam, C A Prows, E D Kharasch, T C Skaar |
| Abstract |
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity. Polymorphisms are a major cause of CYP2D6 variability. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for codeine based on CYP2D6 genotype. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 40% |
| France | 3 | 30% |
| Italy | 1 | 10% |
| Canada | 1 | 10% |
| Unknown | 1 | 10% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Scientists | 2 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 468 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Brazil | 3 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 458 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 75 | 16% |
| Student > Bachelor | 64 | 14% |
| Student > Master | 60 | 13% |
| Student > Ph. D. Student | 45 | 10% |
| Other | 29 | 6% |
| Other | 98 | 21% |
| Unknown | 97 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 104 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 77 | 16% |
| Biochemistry, Genetics and Molecular Biology | 74 | 16% |
| Agricultural and Biological Sciences | 58 | 12% |
| Nursing and Health Professions | 10 | 2% |
| Other | 36 | 8% |
| Unknown | 109 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#1,472,689
of 26,017,215 outputs
Outputs from Clinical Pharmacology & Therapeutics
#204
of 4,619 outputs
Outputs of similar age
#16,270
of 324,891 outputs
Outputs of similar age from Clinical Pharmacology & Therapeutics
#3
of 34 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,619 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,891 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.