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Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging

Overview of attention for article published in Nature Communications, May 2017
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  • Good Attention Score compared to outputs of the same age (71st percentile)

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1 patent

Citations

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174 Dimensions

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174 Mendeley
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Title
Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging
Published in
Nature Communications, May 2017
DOI 10.1038/ncomms15646
Pubmed ID
Authors

Mengmeng Liu, Qian Li, Le Liang, Jiang Li, Kun Wang, Jiajun Li, Min Lv, Nan Chen, Haiyun Song, Joon Lee, Jiye Shi, Lihua Wang, Ratnesh Lal, Chunhai Fan

Abstract

Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticles is essential for designing smart theranostic carriers. Physico-chemical properties, including size, clustering and surface chemistry of nanoparticles regulate their cellular uptake and transport. Significantly, even single nanoparticles could cluster intracellularly, yet their clustering state and subsequent trafficking are not well understood. Here, we used DNA-decorated gold (fPlas-gold) nanoparticles as a dually emissive fluorescent and plasmonic probe to examine their clustering states and intracellular transport. Evidence from correlative fluorescence and plasmonic imaging shows that endocytosis of fPlas-gold follows multiple pathways. In the early stages of endocytosis, fPlas-gold nanoparticles appear mostly as single particles and they cluster during the vesicular transport and maturation. The speed of encapsulated fPlas-gold transport was critically dependent on the size of clusters but not on the types of organelle such as endosomes and lysosomes. Our results provide key strategies for engineering theranostic nanocarriers for efficient health management.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 173 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 33%
Researcher 19 11%
Student > Master 19 11%
Student > Bachelor 19 11%
Student > Doctoral Student 10 6%
Other 21 12%
Unknown 28 16%
Readers by discipline Count As %
Chemistry 29 17%
Agricultural and Biological Sciences 26 15%
Biochemistry, Genetics and Molecular Biology 26 15%
Engineering 16 9%
Physics and Astronomy 7 4%
Other 32 18%
Unknown 38 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#6,404,445
of 25,470,300 outputs
Outputs from Nature Communications
#39,946
of 57,208 outputs
Outputs of similar age
#94,137
of 330,477 outputs
Outputs of similar age from Nature Communications
#783
of 1,075 outputs
Altmetric has tracked 25,470,300 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 57,208 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,477 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 1,075 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.