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Engineered clearing agents for the selective depletion of antigen-specific antibodies

Overview of attention for article published in Nature Communications, May 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

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blogs
1 blog
twitter
4 X users
patent
4 patents

Citations

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34 Dimensions

Readers on

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43 Mendeley
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Title
Engineered clearing agents for the selective depletion of antigen-specific antibodies
Published in
Nature Communications, May 2017
DOI 10.1038/ncomms15314
Pubmed ID
Authors

Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober, E. Sally Ward

Abstract

Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 23%
Student > Ph. D. Student 8 19%
Student > Master 4 9%
Other 4 9%
Professor > Associate Professor 2 5%
Other 2 5%
Unknown 13 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 26%
Agricultural and Biological Sciences 6 14%
Immunology and Microbiology 4 9%
Neuroscience 3 7%
Chemistry 3 7%
Other 5 12%
Unknown 11 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2023.
All research outputs
#2,143,888
of 23,577,654 outputs
Outputs from Nature Communications
#25,165
of 49,108 outputs
Outputs of similar age
#41,990
of 317,529 outputs
Outputs of similar age from Nature Communications
#597
of 1,075 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 49,108 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,529 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 1,075 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.