Title |
Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
|
---|---|
Published in |
Clinical Materials, January 2014
|
DOI | 10.1016/j.biomaterials.2013.12.095 |
Pubmed ID | |
Authors |
Li Li, Wenyi Gu, Jiezhong Chen, Weiyu Chen, Zhi P. Xu |
Abstract |
In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Australia | 1 | <1% |
Saudi Arabia | 1 | <1% |
Unknown | 155 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 22% |
Student > Master | 22 | 14% |
Researcher | 20 | 13% |
Student > Bachelor | 13 | 8% |
Other | 6 | 4% |
Other | 23 | 15% |
Unknown | 39 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 30 | 19% |
Materials Science | 16 | 10% |
Agricultural and Biological Sciences | 13 | 8% |
Engineering | 13 | 8% |
Biochemistry, Genetics and Molecular Biology | 9 | 6% |
Other | 21 | 13% |
Unknown | 56 | 35% |