Title |
Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
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Published in |
Journal of Health, Population and Nutrition, April 2017
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DOI | 10.1186/s41043-017-0087-z |
Pubmed ID | |
Authors |
Aurelie Nguimmo-Metsadjio, Barbara Atogho-Tiedeu, Jean Jacques Noubiap, Marie-Solange Evehe, Rosine Djokam-Dadjeu, Olivier Sontsa Donfack, Dieudonne Nanfa, Edith Pascale M. Mato, Elvis Ndonwi Ngwa, Magellan Guewo-Fokeng, Priscille Pokam-Fosso, Wilfred F. Mbacham, Jean Claude Mbanya, Eugene Sobngwi |
Abstract |
This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population. |
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