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Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.

Overview of attention for article published in Nature, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
86 news outlets
blogs
43 blogs
twitter
881 tweeters
peer_reviews
1 peer review site
facebook
22 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
4 Google+ users
video
1 video uploader

Readers on

mendeley
2062 Mendeley
citeulike
6 CiteULike
Title
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.
Published in
Nature, January 2014
DOI 10.1038/nature12969
Pubmed ID
Authors

Haruko Obokata, Yoshiki Sasai, Hitoshi Niwa, Mitsutaka Kadota, Munazah Andrabi, Nozomu Takata, Mikiko Tokoro, Yukari Terashita, Shigenobu Yonemura, Charles A. Vacanti, Teruhiko Wakayama

Abstract

We recently discovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acquisition of pluripotency (STAP). This reprogramming does not require nuclear transfer or genetic manipulation. Here we report that reprogrammed STAP cells, unlike embryonic stem (ES) cells, can contribute to both embryonic and placental tissues, as seen in a blastocyst injection assay. Mouse STAP cells lose the ability to contribute to the placenta as well as trophoblast marker expression on converting into ES-like stem cells by treatment with adrenocorticotropic hormone (ACTH) and leukaemia inhibitory factor (LIF). In contrast, when cultured with Fgf4, STAP cells give rise to proliferative stem cells with enhanced trophoblastic characteristics. Notably, unlike conventional trophoblast stem cells, the Fgf4-induced stem cells from STAP cells contribute to both embryonic and placental tissues in vivo and transform into ES-like cells when cultured with LIF-containing medium. Taken together, the developmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicates that they represent a unique state of pluripotency.

Twitter Demographics

The data shown below were collected from the profiles of 881 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2,062 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 7 <1%
Spain 1 <1%
Chile 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
China 1 <1%
United States 1 <1%
Unknown 2049 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 1%
Student > Ph. D. Student 24 1%
Professor > Associate Professor 16 <1%
Student > Master 15 <1%
Professor 9 <1%
Other 16 <1%
Unknown 1954 95%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 2%
Medicine and Dentistry 20 <1%
Biochemistry, Genetics and Molecular Biology 8 <1%
Physics and Astronomy 8 <1%
Engineering 4 <1%
Other 19 <1%
Unknown 1954 95%

Attention Score in Context

This research output has an Altmetric Attention Score of 1695. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2017.
All research outputs
#520
of 8,421,724 outputs
Outputs from Nature
#125
of 48,104 outputs
Outputs of similar age
#20
of 195,338 outputs
Outputs of similar age from Nature
#7
of 862 outputs
Altmetric has tracked 8,421,724 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 48,104 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 75.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 862 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.