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RETRACTED ARTICLE: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency

Overview of attention for article published in Nature, January 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
86 news outlets
blogs
40 blogs
twitter
839 tweeters
patent
7 patents
peer_reviews
1 peer review site
facebook
22 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
4 Google+ users
video
1 video uploader

Citations

dimensions_citation
107 Dimensions

Readers on

mendeley
2120 Mendeley
citeulike
6 CiteULike
Title
RETRACTED ARTICLE: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency
Published in
Nature, January 2014
DOI 10.1038/nature12969
Pubmed ID
Authors

Haruko Obokata, Yoshiki Sasai, Hitoshi Niwa, Mitsutaka Kadota, Munazah Andrabi, Nozomu Takata, Mikiko Tokoro, Yukari Terashita, Shigenobu Yonemura, Charles A. Vacanti, Teruhiko Wakayama

Abstract

We recently discovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells by exposure to sublethal stimuli, which we call stimulus-triggered acquisition of pluripotency (STAP). This reprogramming does not require nuclear transfer or genetic manipulation. Here we report that reprogrammed STAP cells, unlike embryonic stem (ES) cells, can contribute to both embryonic and placental tissues, as seen in a blastocyst injection assay. Mouse STAP cells lose the ability to contribute to the placenta as well as trophoblast marker expression on converting into ES-like stem cells by treatment with adrenocorticotropic hormone (ACTH) and leukaemia inhibitory factor (LIF). In contrast, when cultured with Fgf4, STAP cells give rise to proliferative stem cells with enhanced trophoblastic characteristics. Notably, unlike conventional trophoblast stem cells, the Fgf4-induced stem cells from STAP cells contribute to both embryonic and placental tissues in vivo and transform into ES-like cells when cultured with LIF-containing medium. Taken together, the developmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicates that they represent a unique state of pluripotency.

Twitter Demographics

The data shown below were collected from the profiles of 839 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2,120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 74 3%
United States 32 2%
United Kingdom 12 <1%
France 9 <1%
Germany 6 <1%
Spain 5 <1%
Mexico 4 <1%
China 4 <1%
Brazil 4 <1%
Other 30 1%
Unknown 1940 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 576 27%
Student > Ph. D. Student 447 21%
Student > Master 234 11%
Professor > Associate Professor 190 9%
Student > Bachelor 178 8%
Other 495 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 1017 48%
Medicine and Dentistry 305 14%
Biochemistry, Genetics and Molecular Biology 204 10%
Unspecified 109 5%
Chemistry 107 5%
Other 378 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1632. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2019.
All research outputs
#1,323
of 13,628,470 outputs
Outputs from Nature
#230
of 70,229 outputs
Outputs of similar age
#23
of 247,286 outputs
Outputs of similar age from Nature
#6
of 930 outputs
Altmetric has tracked 13,628,470 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 70,229 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 77.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,286 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 930 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.