| Title |
RETRACTED ARTICLE: Stimulus-triggered fate conversion of somatic cells into pluripotency
|
|---|---|
| Published in |
Nature, January 2014
|
| DOI | 10.1038/nature12968 |
| Pubmed ID | |
| Authors |
Haruko Obokata, Teruhiko Wakayama, Yoshiki Sasai, Koji Kojima, Martin P. Vacanti, Hitoshi Niwa, Masayuki Yamato, Charles A. Vacanti |
| Abstract |
Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors. In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Through real-time imaging of STAP cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to STAP cells by reprogramming rather than selection. STAP cells showed a substantial decrease in DNA methylation in the regulatory regions of pluripotency marker genes. Blastocyst injection showed that STAP cells efficiently contribute to chimaeric embryos and to offspring via germline transmission. We also demonstrate the derivation of robustly expandable pluripotent cell lines from STAP cells. Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly converted in a context-dependent manner by strong environmental cues. |
X Demographics
The data shown below were collected from the profiles of 2,155 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 603 | 28% |
| United States | 119 | 6% |
| United Kingdom | 49 | 2% |
| Canada | 20 | <1% |
| Australia | 18 | <1% |
| Spain | 13 | <1% |
| France | 13 | <1% |
| Germany | 12 | <1% |
| China | 8 | <1% |
| Other | 105 | 5% |
| Unknown | 1195 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1921 | 89% |
| Scientists | 181 | 8% |
| Practitioners (doctors, other healthcare professionals) | 28 | 1% |
| Science communicators (journalists, bloggers, editors) | 25 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 4,519 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 123 | 3% |
| United States | 78 | 2% |
| United Kingdom | 42 | <1% |
| Germany | 21 | <1% |
| France | 11 | <1% |
| Spain | 11 | <1% |
| Netherlands | 10 | <1% |
| China | 10 | <1% |
| Brazil | 9 | <1% |
| Other | 84 | 2% |
| Unknown | 4120 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1134 | 25% |
| Student > Ph. D. Student | 945 | 21% |
| Student > Master | 551 | 12% |
| Student > Bachelor | 417 | 9% |
| Professor > Associate Professor | 340 | 8% |
| Other | 852 | 19% |
| Unknown | 280 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1999 | 44% |
| Medicine and Dentistry | 581 | 13% |
| Biochemistry, Genetics and Molecular Biology | 492 | 11% |
| Chemistry | 225 | 5% |
| Engineering | 198 | 4% |
| Other | 650 | 14% |
| Unknown | 374 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3048. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2024.
All research outputs
#2,161
of 25,766,791 outputs
Outputs from Nature
#226
of 98,694 outputs
Outputs of similar age
#8
of 325,397 outputs
Outputs of similar age from Nature
#4
of 888 outputs
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