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Transcriptional Control of Lineage Differentiation in Immune Cells

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Attention for Chapter 375: Transcriptional Control of the Development and Function of Vα14i NKT Cells.
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Chapter title
Transcriptional Control of the Development and Function of Vα14i NKT Cells.
Chapter number 375
Book title
Transcriptional Control of Lineage Differentiation in Immune Cells
Published in
Current topics in microbiology and immunology, May 2014
DOI 10.1007/82_2014_375
Pubmed ID
Book ISBNs
978-3-31-907394-1, 978-3-31-907395-8
Authors

Isaac Engel, Mitchell Kronenberg

Editors

Wilfried Ellmeier, Ichiro Taniuchi

Abstract

The majority of T lymphocytes, sometimes referred to as as mainstream or conventional T cells, are characterized by a diverse T cell antigen receptor (TCR) repertoire. They require antigen priming in order to become memory cells capable of mounting a rapid effector response. It has become established, however, that there are several distinct T cell lineages that exhibit a memory phenotype in the absence of antigen priming, even as they differentiate in the thymus. These lymphocytes typically express a markedly restricted TCR repertoire and their rapid response kinetics has led to their being described as innate-like T cells. In addition, several of these subsets typically express surface markers commonly found on natural killer cells, which has led to the moniker natural killer T cells (NKT cells). This review will describe our current understanding of the unique ways whereby transcription factors control the development and function of an abundant and widely studied lineage of NKT cells that recognizes glycolipid antigens.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 7%
Canada 1 7%
Unknown 12 86%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 50%
Student > Master 3 21%
Researcher 1 7%
Student > Bachelor 1 7%
Unknown 2 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 36%
Immunology and Microbiology 3 21%
Medicine and Dentistry 2 14%
Veterinary Science and Veterinary Medicine 1 7%
Unknown 3 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#18,372,841
of 22,756,196 outputs
Outputs from Current topics in microbiology and immunology
#524
of 671 outputs
Outputs of similar age
#163,807
of 227,399 outputs
Outputs of similar age from Current topics in microbiology and immunology
#7
of 10 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 671 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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