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Transcriptional Control of Lineage Differentiation in Immune Cells

Overview of attention for book
Attention for Chapter 375: Transcriptional Control of the Development and Function of Vα14i NKT Cells.
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Chapter title
Transcriptional Control of the Development and Function of Vα14i NKT Cells.
Chapter number 375
Book title
Transcriptional Control of Lineage Differentiation in Immune Cells
Published in
Current topics in microbiology and immunology, May 2014
DOI 10.1007/82_2014_375
Pubmed ID
Book ISBNs
978-3-31-907394-1, 978-3-31-907395-8
Authors

Isaac Engel, Mitchell Kronenberg

Editors

Wilfried Ellmeier, Ichiro Taniuchi

Abstract

The majority of T lymphocytes, sometimes referred to as as mainstream or conventional T cells, are characterized by a diverse T cell antigen receptor (TCR) repertoire. They require antigen priming in order to become memory cells capable of mounting a rapid effector response. It has become established, however, that there are several distinct T cell lineages that exhibit a memory phenotype in the absence of antigen priming, even as they differentiate in the thymus. These lymphocytes typically express a markedly restricted TCR repertoire and their rapid response kinetics has led to their being described as innate-like T cells. In addition, several of these subsets typically express surface markers commonly found on natural killer cells, which has led to the moniker natural killer T cells (NKT cells). This review will describe our current understanding of the unique ways whereby transcription factors control the development and function of an abundant and widely studied lineage of NKT cells that recognizes glycolipid antigens.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 11%
Canada 1 11%
Unknown 7 78%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 67%
Student > Master 2 22%
Researcher 1 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 56%
Immunology and Microbiology 2 22%
Medicine and Dentistry 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#3,422,691
of 4,833,580 outputs
Outputs from Current topics in microbiology and immunology
#242
of 329 outputs
Outputs of similar age
#77,511
of 115,129 outputs
Outputs of similar age from Current topics in microbiology and immunology
#7
of 8 outputs
Altmetric has tracked 4,833,580 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 329 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 115,129 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.