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Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes

Overview of attention for article published in Journal of Experimental Orthopaedics, February 2017
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Title
Differences in biomarkers of cartilage matrix turnover and their changes over 2 years in adolescent and adult volleyball athletes
Published in
Journal of Experimental Orthopaedics, February 2017
DOI 10.1186/s40634-017-0081-9
Pubmed ID
Authors

Heide Boeth, Aoife MacMahon, A. Robin Poole, Frank Buttgereit, Patrik Önnerfjord, Pilar Lorenzo, Cecilia Klint, Anna Pramhed, Georg N. Duda

Abstract

This study aimed the feasibility to assess longitudinal changes in biomarkers of cartilage turnover and to determine their relationship with patient-rated outcomes over 2 years in volleyball athletes. Thirty-seven athletes were studied: 18 adolescents (age 15.9 ± 0.64 years) in a 2-year intensive volleyball training program and 19 adult recreational volleyball players (age 46.5 ± 4.9 years). Blood and serum samples were taken at baseline (BL) and 2-year follow-up (FU). Subjects completed the International Knee Documentation Committee (IKDC) Subjective Knee Form and the Short-Form 36 (SF-36) at BL. Thirteen adolescents (72%) had open growth plates at BL (BL open adolescents), the rest had closed growth plates at BL (BL closed adolescents), and all but one adolescent had closed growth plates at FU as assessed by MRI. BL open and closed adolescents had greater levels of the cartilage degradation-based biomarkers 45 mer collagenase peptide of type II collagen (C2C-HUSA) and C-telopeptide of type II collagen (CTX-II) than adults. BL open adolescents showed decreases in C2CHUSA, collagen synthesis marker C-propeptide of type II procollagen (CPII), and CTXII, and adults showed increases in cartilage intermediate layer protein 2 (CILP-2) and C2C-HUSA. In adolescents, IKDC scores were correlated with CPII changes. In adults, SF-36 Physical Component Scores were correlated with cartilage oligomeric matrix protein (COMP) changes. Significant differences in biomarker levels over time show the feasibility to assess their changes. Greater levels of C2C-HUSA and CTX-II in adolescents than in adults may reflect increased cartilage turnover in response to higher joint loading. CPII and COMP may be more reflective of subjective patient outcomes. These biomarkers may thus be useful in assessing mechanical loading-induced cartilage changes, their associated symptoms, and Osteoarthritis risk in athletes.

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The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 23%
Other 4 15%
Student > Master 3 12%
Student > Bachelor 2 8%
Student > Ph. D. Student 2 8%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 5 19%
Sports and Recreations 4 15%
Biochemistry, Genetics and Molecular Biology 3 12%
Engineering 2 8%
Agricultural and Biological Sciences 2 8%
Other 4 15%
Unknown 6 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2017.
All research outputs
#9,059,025
of 11,317,953 outputs
Outputs from Journal of Experimental Orthopaedics
#24
of 39 outputs
Outputs of similar age
#192,253
of 267,497 outputs
Outputs of similar age from Journal of Experimental Orthopaedics
#4
of 4 outputs
Altmetric has tracked 11,317,953 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 39 research outputs from this source. They receive a mean Attention Score of 3.0. This one scored the same or higher as 15 of them.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.