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New Approaches to Drug Discovery

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Attention for Chapter 17: In Vivo Target Validation Using Biological Molecules in Drug Development
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Chapter title
In Vivo Target Validation Using Biological Molecules in Drug Development
Chapter number 17
Book title
New Approaches to Drug Discovery
Published in
Handbook of experimental pharmacology, January 2015
DOI 10.1007/164_2015_17
Pubmed ID
Book ISBNs
978-3-31-928912-0, 978-3-31-928914-4
Authors

Derek S. Sim, Katalin Kauser, Sim, Derek S., Kauser, Katalin

Abstract

Drug development is a resource-intensive process requiring significant financial and time investment. Preclinical target validation studies and in vivo testing of the therapeutic molecules in clinically relevant disease models can accelerate and significantly de-risk later stage clinical development. In this chapter, we will focus on (1) in vivo animal models and (2) pharmacological tools for target validation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 31%
Student > Master 3 19%
Student > Ph. D. Student 2 13%
Other 1 6%
Student > Bachelor 1 6%
Other 1 6%
Unknown 3 19%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Pharmacology, Toxicology and Pharmaceutical Science 4 25%
Business, Management and Accounting 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Social Sciences 1 6%
Other 1 6%
Unknown 3 19%