| Chapter title |
Sources for Leads: Natural Products and Libraries
|
|---|---|
| Chapter number | 19 |
| Book title |
New Approaches to Drug Discovery
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/164_2015_19 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-928912-0, 978-3-31-928914-4
|
| Authors |
Eric F. van Herwerden, Roderich D. Süssmuth, Herwerden, Eric F. van, Süssmuth, Roderich D. |
| Abstract |
Natural products have traditionally been a major source of leads in the drug discovery process. However, the development of high-throughput screening led to an increased interest in synthetic methods that enabled the rapid construction of large libraries of molecules. This resulted in the termination or downscaling of many natural product research programs, but the chemical libraries did not necessarily produce a larger amount of drug leads. On one hand, this chapter explores the current state of natural product research within the drug discovery process. On the other hand it evaluates the efforts made to increase the amount of leads generated from chemical libraries and considers what role natural products could play here. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 21% |
| Student > Ph. D. Student | 3 | 13% |
| Unspecified | 1 | 4% |
| Student > Doctoral Student | 1 | 4% |
| Student > Bachelor | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 11 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 5 | 21% |
| Agricultural and Biological Sciences | 4 | 17% |
| Unspecified | 1 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Environmental Science | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 10 | 42% |