| Chapter title |
New Compound Classes: Protein–Protein Interactions
|
|---|---|
| Chapter number | 30 |
| Book title |
New Approaches to Drug Discovery
|
| Published in |
Handbook of experimental pharmacology, January 2015
|
| DOI | 10.1007/164_2015_30 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-928912-0, 978-3-31-928914-4
|
| Authors |
C. Ottmann, Ottmann, C. |
| Abstract |
"Protein-protein interactions (PPIs) are one of the most promising new targets in drug discovery. With estimates between 300,000 and 650,000 in human physiology, targeted modulation of PPIs would tremendously extend the "druggable" genome. In fact, in every disease a wealth of potentially addressable PPIs can be found making pharmacological intervention based on PPI modulators in principle a generally applicable technology. An impressing number of success stories in small-molecule PPI inhibition and natural-product PPI stabilization increasingly encourage academia and industry to invest in PPI modulation. In this chapter examples of both inhibition as well as stabilization of PPIs are reviewed including some of the technologies which has been used for their identification." |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 57% |
| Professor > Associate Professor | 2 | 29% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 43% |
| Agricultural and Biological Sciences | 1 | 14% |
| Immunology and Microbiology | 1 | 14% |
| Chemistry | 1 | 14% |
| Unknown | 1 | 14% |