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New Approaches to Drug Discovery

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Attention for Chapter 24: New Approaches to Drug Discovery
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Chapter title
New Approaches to Drug Discovery
Chapter number 24
Book title
New Approaches to Drug Discovery
Published in
Handbook of experimental pharmacology, September 2015
DOI 10.1007/164_2015_24
Pubmed ID
Book ISBNs
978-3-31-928912-0, 978-3-31-928914-4
Authors

Carrigan, Patricia, Krahn, Thomas, Patricia Carrigan, Thomas Krahn

Abstract

The field of personalized medicine that involves the use of measuring biomarkers in clinical samples is an area of high interest and one that has tremendous impact on drug development. With the emergence of more sensitive and specific technologies that are now able to be run in clinical settings and the ability to accurately measure biomarkers, there is a need to understand how biomarkers are defined, how they are used in clinical trials, and most importantly how they are used in conjunction with drug treatment. Biomarker approaches have entered into early clinical trials and are increasingly being used to develop new diagnostics that help to differentiate or stratify the likely outcomes of therapeutic intervention. Tremendous efforts have been made to date to discover novel biomarkers for use in clinical practice. Still, the number of markers that make it into clinical practice is rather low. In the next following chapters, we will explain the various classifications of biomarkers, how they are applied, measured, and used in personalized medicine specifically focusing on how they are used in de-risking the 10 plus years drug development process and lastly how they are validated and transformed into companion diagnostic assays.

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Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Canada 1 3%
Unknown 38 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Student > Master 6 15%
Student > Bachelor 5 13%
Researcher 4 10%
Student > Doctoral Student 2 5%
Other 6 15%
Unknown 8 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 25%
Medicine and Dentistry 6 15%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Agricultural and Biological Sciences 3 8%
Immunology and Microbiology 2 5%
Other 5 13%
Unknown 10 25%