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A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells

Overview of attention for article published in BMC Cancer, December 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
twitter
1 tweeter

Citations

dimensions_citation
37 Dimensions

Readers on

mendeley
47 Mendeley
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Title
A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells
Published in
BMC Cancer, December 2013
DOI 10.1186/1471-2407-13-569
Pubmed ID
Authors

Martin Grimm, Steffen Schmitt, Peter Teriete, Thorsten Biegner, Arnulf Stenzl, Jörg Hennenlotter, Hans-Joachim Muhs, Adelheid Munz, Tatjana Nadtotschi, Klemens König, Jörg Sänger, Oliver Feyen, Heiko Hofmann, Siegmar Reinert, Johannes F Coy

Abstract

Biomarkers allowing the characterization of malignancy and therapy response of oral squamous cell carcinomas (OSCC) or other types of carcinomas are still outstanding. The biochemical suicide molecule endonuclease DNaseX (DNaseI-like 1) has been used to identify the Apo10 protein epitope that marks tumor cells with abnormal apoptosis and proliferation. The transketolase-like protein 1 (TKTL1) represents the enzymatic basis for an anaerobic glucose metabolism even in the presence of oxygen (aerobic glycolysis/Warburg effect), which is concomitant with a more malignant phenotype due to invasive growth/metastasis and resistance to radical and apoptosis inducing therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 4%
Germany 1 2%
Italy 1 2%
Taiwan 1 2%
Netherlands 1 2%
Unknown 41 87%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 34%
Student > Ph. D. Student 9 19%
Unspecified 8 17%
Student > Master 7 15%
Student > Postgraduate 2 4%
Other 5 11%
Readers by discipline Count As %
Medicine and Dentistry 20 43%
Agricultural and Biological Sciences 8 17%
Unspecified 8 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Physics and Astronomy 2 4%
Other 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2014.
All research outputs
#405,942
of 4,507,509 outputs
Outputs from BMC Cancer
#96
of 2,430 outputs
Outputs of similar age
#14,513
of 123,750 outputs
Outputs of similar age from BMC Cancer
#10
of 107 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,430 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.