Title |
A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells
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Published in |
BMC Cancer, December 2013
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DOI | 10.1186/1471-2407-13-569 |
Pubmed ID | |
Authors |
Martin Grimm, Steffen Schmitt, Peter Teriete, Thorsten Biegner, Arnulf Stenzl, Jörg Hennenlotter, Hans-Joachim Muhs, Adelheid Munz, Tatjana Nadtotschi, Klemens König, Jörg Sänger, Oliver Feyen, Heiko Hofmann, Siegmar Reinert, Johannes F Coy |
Abstract |
Biomarkers allowing the characterization of malignancy and therapy response of oral squamous cell carcinomas (OSCC) or other types of carcinomas are still outstanding. The biochemical suicide molecule endonuclease DNaseX (DNaseI-like 1) has been used to identify the Apo10 protein epitope that marks tumor cells with abnormal apoptosis and proliferation. The transketolase-like protein 1 (TKTL1) represents the enzymatic basis for an anaerobic glucose metabolism even in the presence of oxygen (aerobic glycolysis/Warburg effect), which is concomitant with a more malignant phenotype due to invasive growth/metastasis and resistance to radical and apoptosis inducing therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Netherlands | 1 | 1% |
Germany | 1 | 1% |
Italy | 1 | 1% |
Taiwan | 1 | 1% |
Unknown | 93 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 23 | 23% |
Student > Bachelor | 12 | 12% |
Student > Ph. D. Student | 11 | 11% |
Student > Master | 10 | 10% |
Student > Doctoral Student | 5 | 5% |
Other | 12 | 12% |
Unknown | 26 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 37% |
Agricultural and Biological Sciences | 9 | 9% |
Biochemistry, Genetics and Molecular Biology | 4 | 4% |
Immunology and Microbiology | 4 | 4% |
Unspecified | 3 | 3% |
Other | 14 | 14% |
Unknown | 28 | 28% |