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Neural correlates of ataxia severity in spinocerebellar ataxia type 3/Machado-Joseph disease

Overview of attention for article published in Cerebellum & Ataxias, June 2017
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  • Among the highest-scoring outputs from this source (#35 of 102)
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3 tweeters

Citations

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21 Dimensions

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Title
Neural correlates of ataxia severity in spinocerebellar ataxia type 3/Machado-Joseph disease
Published in
Cerebellum & Ataxias, June 2017
DOI 10.1186/s40673-017-0065-7
Pubmed ID
Authors

Carlos R. Hernandez-Castillo, Rosalinda Diaz, Aurelio Campos-Romo, Juan Fernandez-Ruiz

Abstract

Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant inherited neurodegenerative disorder. Several post-mortem and imaging studies have shown cerebellar and brainstem atrophy. A number of studies have used volumetric regional information to investigate the relationship between neurodegeneration and the ataxia severity. However, regional analysis can obscure the specific location in which the degenerative process is affecting the brain tissue, which can be crucial for the development of new target treatments for this disease. Here we explored the relationship between the gray matter degeneration and the ataxia severity on a cohort of SCA3 patients using a voxel-wise approach. Seventeen patients with molecular diagnose of SCA3 and 17 matched healthy controls participated in this study. Magnetic resonance imaging (MRI) brain images were acquired and voxel-based morphometry was used to obtain the grey matter volume of each participant. Ataxia severity in the patient group was evaluated using the scale for the assessment and rating of ataxia (SARA). Group comparison revealed significant atrophy in SCA3 including bilateral cerebellum, vermis, brainstem, and occipital cortex. Significant negative correlations between gray matter volume and SARA scores were found in the cerebellum and the cingulate gyrus. These findings highlight the specific contribution of the cerebellum and the cingulate cortex to the ataxia deficits among the other regions showing neurodegeneration in SCA3 patients.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 20%
Student > Master 5 14%
Student > Ph. D. Student 5 14%
Researcher 4 11%
Other 2 6%
Other 4 11%
Unknown 8 23%
Readers by discipline Count As %
Neuroscience 9 26%
Nursing and Health Professions 7 20%
Agricultural and Biological Sciences 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Medicine and Dentistry 2 6%
Other 2 6%
Unknown 10 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2017.
All research outputs
#11,980,717
of 20,520,938 outputs
Outputs from Cerebellum & Ataxias
#35
of 102 outputs
Outputs of similar age
#138,110
of 287,123 outputs
Outputs of similar age from Cerebellum & Ataxias
#1
of 1 outputs
Altmetric has tracked 20,520,938 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 102 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,123 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them