Title |
Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits
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Published in |
BMC Complementary Medicine and Therapies, June 2017
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DOI | 10.1186/s12906-017-1809-x |
Pubmed ID | |
Authors |
Raquel Díez, Juan José García, María José Diez, Matilde Sierra, Ana M. Sahagun, Nélida Fernández |
Abstract |
Metformin is an oral hypoglycemic agent frequently used in patients with type 2 diabetes. In this study, we have investigated the influence of the dietary fiber Plantago ovata husk on the pharmacokinetics of this drug when included in the diet, as well as when administered at the same time as metformin. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with fiber (3.5 mg/kg/day). Groups 1 and 4 received metformin intravenously (30 mg/kg). Groups 2 and 5 received metfomin orally (30 mg/kg), and number 3 and 6 were treated orally with metformin (30 mg/kg) and fiber (300 mg/kg). The changes caused by the inclusion of fiber in the feeding were more important in groups that received oral metformin. In this way, metformin oral bioavailability showed an increase of 34.42% when rabbits were fed with supplemented chow. Plantago ovata husk increased the amount of absorbed metformin when included in the diet (significant increase in AUC), and delayed its absorption when administered at the same time (significant increase in tmax). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 5 | 12% |
Other | 5 | 12% |
Researcher | 5 | 12% |
Student > Ph. D. Student | 5 | 12% |
Student > Bachelor | 3 | 7% |
Other | 5 | 12% |
Unknown | 14 | 33% |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
Medicine and Dentistry | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Chemistry | 4 | 10% |
Nursing and Health Professions | 3 | 7% |
Other | 6 | 14% |
Unknown | 16 | 38% |