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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair
|
|---|---|
| Published in |
Cancers, June 2017
|
| DOI | 10.3390/cancers9060066 |
| Pubmed ID | |
| Authors |
Osama Mohamad, Brock J Sishc, Janapriya Saha, Arnold Pompos, Asal Rahimi, Michael D Story, Anthony J Davis, D W Nathan Kim |
| Abstract |
Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical and radiobiological characteristics imbue heavy ions with potent tumoricidal capacity, while having the potential for simultaneously maximally sparing normal tissues. Thus, CIRT could potentially be used to treat some of the most difficult to treat tumors, including those that are hypoxic, radio-resistant, or deep-seated. Clinical data, mostly from Japan and Germany, are promising, with favorable oncologic outcomes and acceptable toxicity. In this manuscript, we review the physical and biological rationales for CIRT, with an emphasis on DNA damage and repair, as well as providing a comprehensive overview of the translational and clinical data using CIRT. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 2 | 67% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Scientists | 1 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 172 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 19% |
| Student > Master | 20 | 12% |
| Researcher | 19 | 11% |
| Student > Bachelor | 15 | 9% |
| Professor > Associate Professor | 9 | 5% |
| Other | 27 | 16% |
| Unknown | 49 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Physics and Astronomy | 31 | 18% |
| Medicine and Dentistry | 30 | 17% |
| Biochemistry, Genetics and Molecular Biology | 17 | 10% |
| Engineering | 12 | 7% |
| Agricultural and Biological Sciences | 11 | 6% |
| Other | 12 | 7% |
| Unknown | 59 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2017.
All research outputs
#14,350,775
of 22,979,862 outputs
Outputs from Cancers
#5,436
of 12,677 outputs
Outputs of similar age
#176,933
of 317,132 outputs
Outputs of similar age from Cancers
#29
of 54 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,677 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,132 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.