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Mendeley readers
Attention Score in Context
| Title |
Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
|
|---|---|
| Published in |
Acta Neuropathologica Communications, June 2017
|
| DOI | 10.1186/s40478-017-0445-5 |
| Pubmed ID | |
| Authors |
Jennifer Ngolab, Ivy Trinh, Edward Rockenstein, Michael Mante, Jazmin Florio, Margarita Trejo, Deborah Masliah, Anthony Adame, Eliezer Masliah, Robert A. Rissman |
| Abstract |
Proteins implicated in neurodegenerative conditions such as Alzheimer's disease (AD) and Dementia with Lewy Bodies (DLB) have been identified in bodily fluids encased in extracellular vesicles called exosomes. Whether exosomes found in DLB patients can transmit pathology is not clear. In this study, exosomes were successfully harvested through ultracentrifugation from brain tissue from DLB and AD patients as well as non-diseased brain tissue. Exosomes extracted from brains diagnosed with either AD or DLB contained aggregate-prone proteins. Furthermore, injection of brain-derived exosomes from DLB patients into the brains of wild type mice induced α-synuclein (α-syn) aggregation. As assessed through immunofluorescent double labeling, α-syn aggregation was observed in MAP2(+), Rab5(+) neurons. Using a neuronal cell line, we also identified intracellular α-syn aggregation mediated by exosomes is dependent on recipient cell endocytosis. Together, these data suggest that exosomes from DLB patients are sufficient for seeding and propagating α-syn aggregation in vivo. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 252 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 251 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 21% |
| Researcher | 36 | 14% |
| Student > Bachelor | 26 | 10% |
| Student > Master | 20 | 8% |
| Student > Doctoral Student | 12 | 5% |
| Other | 40 | 16% |
| Unknown | 64 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 51 | 20% |
| Biochemistry, Genetics and Molecular Biology | 50 | 20% |
| Agricultural and Biological Sciences | 38 | 15% |
| Medicine and Dentistry | 17 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
| Other | 18 | 7% |
| Unknown | 72 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2018.
All research outputs
#2,845,107
of 22,979,862 outputs
Outputs from Acta Neuropathologica Communications
#532
of 1,391 outputs
Outputs of similar age
#54,746
of 317,132 outputs
Outputs of similar age from Acta Neuropathologica Communications
#10
of 23 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,391 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,132 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.