You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
| Title |
Orally delivered water soluble Coenzyme Q10 (Ubisol-Q10) blocks on-going neurodegeneration in rats exposed to paraquat: potential for therapeutic application in Parkinson’s disease
|
|---|---|
| Published in |
BMC Neuroscience, January 2014
|
| DOI | 10.1186/1471-2202-15-21 |
| Pubmed ID | |
| Authors |
Krithika Muthukumaran, Samantha Leahy, Kate Harrison, Marianna Sikorska, Jagdeep K Sandhu, Jerome Cohen, Corrine Keshan, Daniel Lopatin, Harvey Miller, Henryk Borowy-Borowski, Patricia Lanthier, Shelly Weinstock, Siyaram Pandey |
| Abstract |
Paraquat, still used as an herbicide in some parts of the world, is now regarded as a dangerous environmental neurotoxin and is linked to the development Parkinson's disease (PD). Paraquat interacts with cellular redox systems and causes mitochondrial dysfunction and the formation of reactive oxygen species, which in turn, plays a crucial role in the pathophysiology of PD. Various antioxidant therapies have been explored with the expectations that they deliver health benefits to the PD patients, however, no such therapies were effective. Here we have tested the neuroprotective efficacy of a novel water-soluble CoQ10 (Ubisol-Q10), in a rat model of paraquat-induced neurodegeneration in order to evaluate its potential application in the management of PD. |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 74 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 16% |
| Student > Master | 10 | 13% |
| Researcher | 7 | 9% |
| Other | 6 | 8% |
| Lecturer | 5 | 7% |
| Other | 17 | 23% |
| Unknown | 18 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 15% |
| Agricultural and Biological Sciences | 10 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 11% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Neuroscience | 5 | 7% |
| Other | 10 | 13% |
| Unknown | 24 | 32% |