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Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast

Overview of attention for article published in Frontiers in Genetics, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters
peer_reviews
1 peer review site

Citations

dimensions_citation
183 Dimensions

Readers on

mendeley
61 Mendeley
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Title
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Published in
Frontiers in Genetics, January 2014
DOI 10.3389/fgene.2014.00001
Pubmed ID
Authors

Daniel A. Medina, Antonio Jordán-Pla, Gonzalo Millán-Zambrano, Sebastián Chávez, Mordechai Choder, José E. Pérez-Ortín

Abstract

The 5' to 3' exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects. In a previous study, our group showed that deletion of all tested components of the yeast major decaysome, including XRN1, results in a decrease in the synthetic rate and an increase in half-life of most mRNAs in a compensatory manner. Furthermore, the same study showed that the all tested decaysome components are also nuclear proteins that bind to the 5' region of a number of genes. In the present work, we show that disruption of Xrn1 activity preferentially affects both the synthesis and decay of a distinct subpopulation of mRNAs. The most affected mRNAs are the transcripts of the highly transcribed genes, mainly those encoding ribosome biogenesis and translation factors. Previously, we proposed that synthegradases play a key role in regulating both mRNA synthesis and degradation. Evidently, Xrn1 functions as a synthegradase, whose selectivity might help coordinating the expression of the protein synthetic machinery. We propose to name the most affected genes "Xrn1 synthegradon."

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Argentina 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 43%
Researcher 8 13%
Professor > Associate Professor 5 8%
Student > Doctoral Student 4 7%
Student > Master 4 7%
Other 14 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 54%
Biochemistry, Genetics and Molecular Biology 25 41%
Unspecified 1 2%
Neuroscience 1 2%
Medicine and Dentistry 1 2%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.
All research outputs
#1,228,135
of 12,378,687 outputs
Outputs from Frontiers in Genetics
#253
of 2,543 outputs
Outputs of similar age
#25,432
of 227,886 outputs
Outputs of similar age from Frontiers in Genetics
#13
of 76 outputs
Altmetric has tracked 12,378,687 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,543 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.