Title |
Targeting the PDGF signaling pathway in tumor treatment
|
---|---|
Published in |
Cell Communication and Signaling, December 2013
|
DOI | 10.1186/1478-811x-11-97 |
Pubmed ID | |
Authors |
Carl-Henrik Heldin |
Abstract |
Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the adult. Overactivity of PDGF receptor signaling, by overexpression or mutational events, may drive tumor cell growth. In addition, pericytes of the vasculature and fibroblasts and myofibroblasts of the stroma of solid tumors express PDGF receptors, and PDGF stimulation of such cells promotes tumorigenesis. Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. Whether treatment with PDGF/PDGF receptor antagonists will be beneficial for more common malignancies is the subject for ongoing studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
Germany | 1 | <1% |
Italy | 1 | <1% |
Austria | 1 | <1% |
India | 1 | <1% |
Mexico | 1 | <1% |
Japan | 1 | <1% |
Unknown | 492 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 118 | 24% |
Researcher | 68 | 14% |
Student > Master | 57 | 11% |
Student > Bachelor | 57 | 11% |
Student > Doctoral Student | 31 | 6% |
Other | 79 | 16% |
Unknown | 89 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 120 | 24% |
Biochemistry, Genetics and Molecular Biology | 108 | 22% |
Medicine and Dentistry | 89 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 4% |
Engineering | 13 | 3% |
Other | 48 | 10% |
Unknown | 103 | 21% |