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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A fully functional drug-eluting joint implant
|
|---|---|
| Published in |
Nature Biomedical Engineering, June 2017
|
| DOI | 10.1038/s41551-017-0080 |
| Pubmed ID | |
| Authors |
V. J. Suhardi, D. A. Bichara, S. J. J. Kwok, A. A. Freiberg, H. Rubash, H. Malchau, S. H. Yun, O. K. Muratoglu, E. Oral |
| Abstract |
Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) results in maximized drug elution and in the retention of mechanical strength. The optimized UHMWPE eluted antibiotic at a higher concentration for longer than the clinical gold standard antibiotic-eluting bone cement while retaining the mechanical and wear properties of clinically used UHMWPE joint prostheses. Treatment of lapine knees infected with Staphylococcus aureus with the antibiotic-eluting UHMWPE led to complete bacterial eradication and to the absence of detectable systemic effects. We argue that the antibiotic-eluting UHMWPE joint implant is a promising candidate for clinical trials. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 28% |
| United Kingdom | 2 | 8% |
| South Africa | 2 | 8% |
| Nigeria | 1 | 4% |
| Spain | 1 | 4% |
| Germany | 1 | 4% |
| Canada | 1 | 4% |
| Ireland | 1 | 4% |
| Japan | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 6 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 56% |
| Scientists | 7 | 28% |
| Science communicators (journalists, bloggers, editors) | 3 | 12% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 21% |
| Student > Master | 15 | 13% |
| Researcher | 10 | 9% |
| Student > Bachelor | 9 | 8% |
| Student > Postgraduate | 5 | 4% |
| Other | 14 | 12% |
| Unknown | 36 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 21 | 19% |
| Materials Science | 17 | 15% |
| Medicine and Dentistry | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Chemistry | 4 | 4% |
| Other | 23 | 20% |
| Unknown | 35 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2023.
All research outputs
#359,979
of 25,375,376 outputs
Outputs from Nature Biomedical Engineering
#240
of 1,128 outputs
Outputs of similar age
#7,580
of 324,066 outputs
Outputs of similar age from Nature Biomedical Engineering
#10
of 37 outputs
Altmetric has tracked 25,375,376 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,128 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 86.9. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,066 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.