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Vaccines for Invasive Fungal Infections

Overview of attention for book
Cover of 'Vaccines for Invasive Fungal Infections'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Mouse Immunization with Radioattenuated Yeast Cells of Paracoccidioides brasiliensis
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    Chapter 2 Heat-Killed Yeast as a Pan-Fungal Vaccine
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    Chapter 3 Immunoinformatics as a Tool for New Antifungal Vaccines
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    Chapter 4 Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection
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    Chapter 5 Identification of Fungal T Cell Epitopes by Mass Spectrometry-Based Proteomics
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    Chapter 6 Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells
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    Chapter 7 DNAhsp65 Vaccine as Therapy against Paracoccidioidomycosis
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    Chapter 8 Idiotypic Antifungal Vaccination: Immunoprotection by Antiidiotypic Antibiotic Antibodies
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    Chapter 9 Peptide Vaccine Against Paracoccidioidomycosis
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    Chapter 10 Methodology for Anti-Cryptococcal Vaccine Development
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    Chapter 11 Beta-Glucan Particles as Vaccine Adjuvant Carriers
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    Chapter 12 Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis
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    Chapter 13 Nanoparticle-Based Mycosis Vaccine
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    Chapter 14 Yeast Expressing Gp43 Protein as a Vaccine Against Paracoccidioides brasiliensis Infection
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    Chapter 15 Vaccination with Phage-Displayed Antigenic Epitope
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    Chapter 16 Preparation of an Oral Vaccine by Proteome Analysis and Molecular Display Technology
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    Chapter 17 Precise and Efficient In-Frame Integration of an Exogenous GFP Tag in Aspergillus fumigatus by a CRISPR System
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    Chapter 18 Endpoint Assessment in Rabbit Models of Invasive Pulmonary Aspergillosis and Mucormycosis
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    Chapter 19 CD4+ T Cells Mediate Aspergillosis Vaccine Protection
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    Chapter 20 T-Cell-Mediated Cross-Protective Immunity
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    Chapter 21 Assessment of Post-Vaccination Phagocytic Activation Using Candida albicans Killing Assays
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    Chapter 22 Immunization with Antigen-Pulsed Dendritic Cells Against Highly Virulent Cryptococcus gattii Infection: Analysis of Cytokine-Producing T Cells
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    Chapter 23 Testing Antifungal Vaccines in an Animal Model of Invasive Candidiasis and in Human Mucosal Candidiasis
Attention for Chapter 11: Beta-Glucan Particles as Vaccine Adjuvant Carriers
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Chapter title
Beta-Glucan Particles as Vaccine Adjuvant Carriers
Chapter number 11
Book title
Vaccines for Invasive Fungal Infections
Published in
Methods in molecular biology, June 2017
DOI 10.1007/978-1-4939-7104-6_11
Pubmed ID
Book ISBNs
978-1-4939-7103-9, 978-1-4939-7104-6
Authors

Mirza, Zeynep, Soto, Ernesto R., Dikengil, Fusun, Levitz, Stuart M., Ostroff, Gary R., Zeynep Mirza, Ernesto R. Soto, Fusun Dikengil, Stuart M. Levitz, Gary R. Ostroff

Editors

Markus Kalkum, Margarita Semis

Abstract

Glucan particles (GPs) are spherical hollow particles derived from Saccharomyces cerevisiae cell walls and mainly consist of β-1, 3-D-glucans. The inner hollow cavity of glucan particles can be loaded with different compounds, including protein antigens, and delivered to macrophages and dendritic cells. Moreover, the GP delivery system possesses β-glucan's intrinsic immunostimulatory properties. Therefore, GPs serve as both an antigen-presenting cell-targeted delivery system and an adjuvant.Here, we describe the production of GPs from S. cerevisiae using hot alkaline and solvent extraction and characterization of these particles for morphology, particle density, and hydrodynamic volume. A detailed protocol for loading and entrapping a model antigen, ovalbumin (OVA), into these particles using yeast RNA is presented. Similar methods are used to load pathogen-specific antigens (peptides, proteins, soluble extracts) which then can be tested in in vivo vaccination models.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 18%
Student > Doctoral Student 2 12%
Student > Master 2 12%
Student > Ph. D. Student 1 6%
Other 1 6%
Other 1 6%
Unknown 7 41%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Chemical Engineering 1 6%
Unspecified 1 6%
Agricultural and Biological Sciences 1 6%
Immunology and Microbiology 1 6%
Other 0 0%
Unknown 10 59%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2019.
All research outputs
#8,432,435
of 14,580,034 outputs
Outputs from Methods in molecular biology
#2,364
of 8,766 outputs
Outputs of similar age
#132,324
of 268,480 outputs
Outputs of similar age from Methods in molecular biology
#7
of 23 outputs
Altmetric has tracked 14,580,034 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,766 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,480 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.