Chapter title |
Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells
|
---|---|
Chapter number | 6 |
Book title |
Vaccines for Invasive Fungal Infections
|
Published in |
Methods in molecular biology, June 2017
|
DOI | 10.1007/978-1-4939-7104-6_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7103-9, 978-1-4939-7104-6
|
Authors |
Awasthi, Shanjana, Shanjana Awasthi Ph.D., Shanjana Awasthi |
Editors |
Markus Kalkum, Margarita Semis |
Abstract |
Dendritic cells are the most potent antigen-presenting cells, and are critical for the generation of an antigen-specific immune response and protective immunity. These unique features have been applied to dendritic cell-based immunization in a number of disease conditions. Our published results have demonstrated that the immunity induced by intranasal immunization with DNA-transfected dendritic cells results in reduced fungal burden, and alleviated lung tissue damage in a mouse model of pulmonary fungal infection. In this article, approaches for the preparation and characterization of DNA-transfected dendritic cells and intranasal immunization in mice are described. |
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