Chapter title |
Identification of Fungal T Cell Epitopes by Mass Spectrometry-Based Proteomics
|
---|---|
Chapter number | 5 |
Book title |
Vaccines for Invasive Fungal Infections
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7104-6_5 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7103-9, 978-1-4939-7104-6
|
Authors |
Bernd Roschitzki, Salomé LeibundGut-Landmann, Roschitzki, Bernd, LeibundGut-Landmann, Salomé |
Editors |
Markus Kalkum, Margarita Semis |
Abstract |
CD4(+) T cells play a key role in host defense against many fungal infections. T cells are also implicated in vaccine immunity to fungi. To date, only a small number of fungal antigens have been identified. Knowing the antigenic determinants of fungi-specific T cells greatly facilitates the detection, enumeration and characterizes the antifungal T cells and it constitutes an important step toward the design and development of vaccination strategies. This chapter describes a method of MHC-II ligand elution and mass spectrometric analysis to identify naturally processed and presented fungal peptide epitopes. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 30% |
Unspecified | 1 | 10% |
Student > Bachelor | 1 | 10% |
Student > Master | 1 | 10% |
Unknown | 4 | 40% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Agricultural and Biological Sciences | 2 | 20% |
Unspecified | 1 | 10% |
Engineering | 1 | 10% |
Unknown | 4 | 40% |